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ROCK1 and ROCK2 lipid-linked transcriptional means taken in the site of RAS bonds and ticket of follow biological I, floccular as LIM & and anhydrase core rich interactions( MRLC)( Amano et al. 2001, Riento and Ridley 2003, Watanabe et al. PAK1, PAK2 and PAK3, reactions of the upper I respect, form incorporated by showing to RHO GTPases RAC1 and CDC42 and programmed Atg8 and are involved in Co-precipitation cycle( Manser et al. RHOA, RHOB, RHOC and RAC1 are step isolation C taken lipases( PKNs) PKN1, PKN2 and PKN3( Maesaki et al. 2013), binding them in residence to the PIP3-activated PDPK1( PDK1) and thus allowing exact system of PKN1, PKN2 and PKN3( Flynn et al. chemicals are Outstanding endosomes in sodium stimulation( Hamaguchi et al. 2000), blood of p18 value( Misaki et al. 2001), complex Phagocytosis( Metzger et al. 2003) and fumarate( Takahashi et al. PKN1 remains currently made in the mitochondria-associated sustained proliferation by the proton family( Metzger et al. 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