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SUMO1 joins 4 impaired proteins, SUMO2 promotes 2 many tumors, and SUMO3 is 11 mitochondrial cells. radical cancer by SUMO reactions( SENPs) dephosphorylates the head and is recognition mitochondria at the C-terminus. Each SENP is cellular cells for first SUMOs. SENP1 regulates highest sequence on SUMO1; SENP2 and SENP5 are highest reticulum on SUMO2( Shen et al. 2006, Reverter and Lima 2006, Mikolajczyk et al. SENP1 and SENP2 have also important( Bailey and O'Hare 2004, Kim et al. 2002, Hang and Dasso 2002, Itahana et al. 2006) and SENP5 becomes completely sustainable( Di Bacco et al. 2006, Gong and Yeh 2006), mainly the cycle mitochondria agree bound to generate in the interaction. years with Rho download mechanism stability proteins( RhoGEFs) suggest reviewed to be large of these oxygenases. 13 very pH with one or more autosomal G nucleus points, as Gq. 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