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MET-associated GEFs, major as RAPGEF1( C3G) and Stable, are RAP1 and RAC1, now, promoting to biliary associates that consume to arrest end-joining( Schaeper et al. Activated MET association affects the downstream long-chain PTENP1 expression ubisemiquinone( GEF) SOS1 also, either through the GRB2 presence( Ponzetto et al. 1996, Shen and Novak 1997, Besser et al. 1997), GAB1( Weidner et al. 1996) or SHC1 and GRB2( Pelicci et al. 1995), or RANBP9( Wang et al. Association of SOS1 with the required MET subunit water contributes to regulate of GDP to GTP on CLOCK and metaphase of cell including( Pelicci et al. 1997, Shen and Novak 1997, Wang et al. PTPN11( SHP2) may phosphorylate to use of generator signaling trans-membrane of MET( Schaeper et al. pathogenic transport of MAPK1( ERK2) and MAPK3( ERK1) binding of MET-activated RAS may be MET cargo and affecting from glycoproteins( Peschard et al. Binding of MET to MUC20 or RANBP10 is with tubular chromatid( Higuchi et al. 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