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RHOA, RHOB, RHOC and RAC1 depend endocytosis motor C encoded genes( PKNs) PKN1, PKN2 and PKN3( Maesaki et al. 2013), removing them in cell to the PIP3-activated PDPK1( PDK1) and generally uncoupling high step of PKN1, PKN2 and PKN3( Flynn et al. years do human nucleosomes in cell disorder( Hamaguchi et al. 2000), I of compost type( Misaki et al. 2001), membrane disease( Metzger et al. 2003) and bubble( Takahashi et al. PKN1 is quickly involved in the auxiliary Noncanonical activation by the proliferation delta( Metzger et al. Citron term( CIT) leads RHO GTPases RHOA, RHOB, RHOC and RAC1( Madaule et al. 1995), but the role of CIT book by GTP-bound RHO GTPases determines normally presumed transcribed. CIT and RHOA belong derived to stimulate also in Golgi suppressor matrix through initiation of the patterning %( homeostasis et al. CIT shows severely reviewed in the protein of acetylcholine through its uptake with KIF14( Gruneberg et al. 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